收费全文 | 232171篇 |
免费 | 15293篇 |
国内免费 | 978篇 |
耳鼻咽喉 | 2522篇 |
儿科学 | 5962篇 |
妇产科学 | 4393篇 |
基础医学 | 28994篇 |
口腔科学 | 4311篇 |
临床医学 | 23787篇 |
内科学 | 48611篇 |
皮肤病学 | 3216篇 |
神经病学 | 23463篇 |
特种医学 | 10105篇 |
外国民族医学 | 13篇 |
外科学 | 36866篇 |
综合类 | 2509篇 |
现状与发展 | 1篇 |
一般理论 | 177篇 |
预防医学 | 16231篇 |
眼科学 | 5506篇 |
药学 | 15426篇 |
1篇 | |
中国医学 | 318篇 |
肿瘤学 | 16030篇 |
2023年 | 1226篇 |
2022年 | 848篇 |
2021年 | 5208篇 |
2020年 | 3043篇 |
2019年 | 5052篇 |
2018年 | 6048篇 |
2017年 | 4439篇 |
2016年 | 4853篇 |
2015年 | 5732篇 |
2014年 | 8350篇 |
2013年 | 11246篇 |
2012年 | 17278篇 |
2011年 | 18013篇 |
2010年 | 10067篇 |
2009年 | 9310篇 |
2008年 | 15861篇 |
2007年 | 16653篇 |
2006年 | 16196篇 |
2005年 | 16052篇 |
2004年 | 15103篇 |
2003年 | 13785篇 |
2002年 | 13186篇 |
2001年 | 1931篇 |
2000年 | 1430篇 |
1999年 | 2007篇 |
1998年 | 2788篇 |
1997年 | 2185篇 |
1996年 | 1539篇 |
1995年 | 1704篇 |
1994年 | 1485篇 |
1993年 | 1455篇 |
1992年 | 937篇 |
1991年 | 914篇 |
1990年 | 768篇 |
1989年 | 724篇 |
1988年 | 666篇 |
1987年 | 599篇 |
1986年 | 622篇 |
1985年 | 672篇 |
1984年 | 886篇 |
1983年 | 768篇 |
1982年 | 1011篇 |
1981年 | 940篇 |
1980年 | 823篇 |
1979年 | 444篇 |
1978年 | 496篇 |
1977年 | 430篇 |
1976年 | 400篇 |
1975年 | 299篇 |
1974年 | 304篇 |
We discuss an epileptic incident in an undiagnosed 13-year old girl participating in a clinical study investigating the effects of transcranial direct current stimulation (tDCS) in healthy children and adolescents. This incident poses important research ethics questions with regard to study design, especially pertaining to screening and gaining informed consent. Potential benefits and problems of the incident also need to be considered. The ethical analysis of the case presented in this paper has been informed by an in-depth interview conducted after the incident with the child and the accompanying parent. We discuss the ethical implications of the epileptic incident, the need for improving screening procedures for studies with minors and for providing more effective communication. This case also underscores the problem of undetected teenage epilepsy in neuropsychological clinical studies and the necessity of raising more awareness of this issue. Since research in tDCS is an active and expanding field, we conclude with providing some recommendation that could ensure that future research on tDCS, or other therapies and neuro-interventions where there is a risk of triggering an epileptic seizure, take into account the specifics of teenage epilepsy and the need for more thorough provision of information during the process of gaining informed consent.
相似文献Areas covered: This review provides an overview of existing pharmacotherapy for osteoporosis in women and explore state-of–the-art and emerging therapies to prevent bone loss, with an emphasis on the mechanism of action, indications and side effects.
Expert opinion: Bisphosphonates appear to be a reliable and cost-effective option, whereas denosumab has introduced a simpler dosing regimen and may achieve a linear increase in bone mineral density (BMD) with no plateau being observed, along with continuous anti-fracture efficacy. Abaloparatide, a parathyroid-hormone-related peptide (PTHrP)-analogue, approved by the FDA in April 2017, constitutes the first new anabolic osteoporosis drug in the US for nearly 15 years and has also proven its anti-fracture efficacy. Romosozumab, a sclerostin inhibitor, which induces bone formation and suppresses bone resorption, has also been developed and shown a significant reduction in fracture incidence; however, concerns have arisen with regard to increased cardiovascular risk. 相似文献